Hilton Hotels & Resorts is set to expand its footprint in Northeast Florida with the highly anticipated opening of Hilton Jacksonville at Mayo Clinic in October 2025.
Strategically located with direct access to the world-renowned Mayo Clinic Hospital, the hotel will offer a seamless blend of Hilton’s signature hospitality and the clinical excellence of one of America’s leading medical institutions.
Just minutes from Jacksonville’s pristine beaches and vibrant downtown attractions—including St. Johns Town Centre and EverBank Stadium—the property is designed to serve both business and leisure travellers.
Featuring over 250 elegantly appointed guest rooms and suites tailored for short and extended stays, the hotel will also include 21,000 square feet of flexible meeting space, ideal for everything from high-level conferences to private celebrations.
Guests will enjoy all-day dining at Coastal Kitchen, where a hearty breakfast buffet transitions into a menu of locally inspired dishes crafted with seasonal ingredients and regional flair.